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Compound research

What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial 12S rRNA. Published work includes cell and animal metabolic models; those findings do not establish human safety, efficacy, or product quality.

View MOTS-cCheck batch records
Research compoundMOTS-c
CAS number1627580-64-6
Molecular formulaC101H152N28O22S2
Molecular weight2174.62 g/mol

Source trail

Selected references

  1. Cell and animal study

    The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

    Lee C, Zeng J, Drew BG, et al. Cell Metabolism (2015).

    Foundational study identifying MOTS-c and examining metabolic signaling in experimental models.

    PMID 25738459 · DOI 10.1016/j.cmet.2015.02.009

  2. Scientific review

    MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

    Zheng Y, Wei Z, Wang T, et al. Frontiers in Endocrinology (2023).

    Reviews MOTS-c biology and clearly reflects an emerging, mostly preclinical evidence base.

    PMID 36761202 · DOI 10.3389/fendo.2023.1120533

How to interpret this page

These sources establish research context only. They do not verify an Astral lot, support dosing or human use, or prove safety or efficacy. Use the lot-specific COA for analytical evidence.

Editorially curated and source-verified; not independently peer-reviewed by Astral. Last source check: 2026-07-21. Read the editorial policy.